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May 11, 2020
Category: News
Posted by: geneticsadmin
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Dr. Surajit Sarkar

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Lab strip

 Neurobiology and Developmental Genetics Laboratory

Human neurodegenerative disorders are devastating illnesses characterized by progressive loss of neurons in specific areas of brain causing various neurological complications leading to death. Some of these disorders include Parkinson's disease, Alzheimer's disease, Spinal and bulbar Muscular atrophy (SBMA), Dentatorubral pallidoluysian atrophy, Huntington’s disease (HD) and several kinds of the Spinocerebellar ataxias etc.

Our research interest is primarily focused on to unravel the cellular and molecular basis of human neurodegenerative disorders, and to identify the amicable drug target to restrict the pathogenesis of such devastating human illnesses. In addition, we are also interested to study the developmental relevance of the multiple globin genes in Drosophila.

Our Research Findings in Print and Electronic Media

News papers

Selected Publications:

  • Pragati, Chanu SI, Sarkar S. (2019) Reduced expression of dMyc mitigates TauV337M mediated neurotoxicity by preventing the Tau hyperphosphorylation and inducing autophagy in Drosophila. Neurosci Lett. doi: 10.1016/j.neulet.2019.134622. [Epub ahead of print]
  • Nisha, Aggarwal P, Sarkar S. (2019) Adequate expression of Globin1 is required for development and maintenance of nervous system in Drosophila. Mol Cell Neurosci. 100:103398.
  • Raj K, Sarkar S. (2019) Tissue-Specific Upregulation of Drosophila Insulin Receptor (InR) Mitigates Poly(Q)-Mediated Neurotoxicity by Restoration of Cellular Transcription Machinery. Mol Neurobiol. 56:1310-1329.
  • Yadav R, Nisha, Sarkar S. (2018) Drosophila globin1 is required for maintenance of the integrity of F-actin based cytoskeleton during development. Exp Cell Res. 366:16-23.
  • Sarkar S. (2018) Neurofibrillary tangles (NFTs) mediated human neuronal tauopathies: Insights from fly models. J. Genet. 97:783-793.
  • Chanu SI. Sarkar S. (2017) Targeted downregulation of dMyc restricts neurofibrillary tangles mediated pathogenesis of human neuronal tauopathies in Drosophila. Biochim Biophys Acta Mol Basis Dis. 1863:2111-2119.
  • Raj K. and Sarkar S (2017) Transactivation domain of human c-myc is essential to alleviate poly(Q) mediated neurotoxicity in Drosophila disease models. J. Mol Neurosci 62:55-66.
  • Chanu SI, Sarkar S. (2017) Targeted Downregulation of dMyc Suppresses Pathogenesis of Human Neuronal Tauopathies in Drosophila by Limiting Heterochromatin Relaxation and Tau Hyperphosphorylation. Mol Neurobiol. 54:2706-2719
  • Yadav R., Sarkar S. (2016) Drosophila glob1 is required for the maintenance of cytoskeletal integrity during oogenesis. Dev. Dyn. 245:1048-1065
  • Yadav R., Chanu SI., Raj K. Nisha., Sarkar S (2016) Drosophila melanogaster: A prime experimental model system for aging studies. In: Topics in Biomedical Gerontology; Eds. P.C. Rath, R. Sharma, S. Prasad. Springer Publication.
  • Singh MD, Chanu SI, Sarkar S. (2016) Deciphering the Enigma of Human Poly(Q) Disorders: Contribution of Drosophila melanogaster. Int J Neu Res 2: 216-223.
  • Yadav R, Kundu S, Sarkar S (2015) Drosophila glob1 expresses dynamically and is required for development and oxidative stress response. Genesis 53:719-737. (Cover Page Article)
  • Raj K, Chanu SI, Sarkar S (2015) Protein Misfolding and Aggregation in Neurodegenerative Disorders: Focus on Chaperone-Mediated Protein Folding Machinery. Int J Neu Res 1(2): 72-78.
  • Chanu S.I, Singh, M.D., Nisha. And Sarkar S (2014) Transcriptional up-regulation and its impact on poly(Q) disorders. Ther Tar Neurol Dis 2014; 1: e312. doi: 10.14800/ttnd.312.
  • Gupta R., Sarkar S. and Srivastava S (2014) In vivo Toxicity Assessment of Antimicrobial Peptides (AMPs LR14) Derived from Lactobacillus plantarum Strain LR/14 in Drosophila melanogaster. Probiotics & Antimicro. Prot. 6: 59-67. 
  • Singh M.D., Raj K., Sarkar S. (2014) Drosophila Myc, a novel modifier suppresses the poly(Q) toxicity by modulating the level of CREB binding protein and histone acetylation, Neurobiol. Dis. 63:48-61
  • Chanu SI, Singh MD, Yadav R, Raj K. Sarkar S (2013) Neurodegeneration and Ageing: A Fatal Encounter. Cell Dev Biol S1:002. doi: 10.4172/2168-9296.S1-002.
  • Sarkar. S., Singh M.D. Yadav R and Pittman G. W. (2011) Heat shock proteins: Molecules with assorted functions. Front Bio. 6: 312-327.
  • Sarkar S. and Lakhotia S. C. (2008) Hsp60C is required in follicle as well as germline cells during oogenesis in Drosophila melanogaster. Dev. Dyn. 237:1334-1347. (Cover Page Article)
  • Sarkar S, Arya R, Lakhotia S. C. (2006). Chaperonins: in life and death. In: Sreedhar AS, Srinivas UK, editors. Stress Responses: A Molecular Biology Approach. Research Signpost Publication.
  • Sarkar S. and Lakhotia S. C. (2005). The Hsp60C gene in the 25F cytogenetic region in Drosophila melanogaster is essential for tracheal development fertility. J. Genet, 84: 265-281.
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