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CMS - 2.2.10 - Spuzzum
 

Dr. Aruna Naorem

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Dictyostelium discoideum cells respond to nutrient starvation by secreting cAMP and cAMP induced aggregation of unicellular amoebae into multicellular fruiting body which consists of three different types of differentiated cells: spores, stalk and basal disc cells. The starvation-induced developmental program is accompanied by changes in gene expression in a tightly controlled manner. The main aim of our laboratory is to understand the regulatory mechanisms both transcriptional and post-translational controls underlying cellular differentiation during starvation-induced development in D. discoideum. To achieve the aim, studies in the lab involve three different approaches - gene-specific transcription factors e.g. bZIP and genes regulated by them; Parvulins, a family of Peptidyl prolyl cis/trans isomerase (PPIase) in regulating the effector molecules such as transcription factors; cell cycle regulator, e.g. Wee family kinases, as cell cycle influences cell differentiation; and finally integration of the molecular events in understanding how the action of these regulatory protein in concert to achieve a complex process of cell differentiation during multicellular development.

Selected publications:

  • Tanwar M, Khera L, Haokip N, Kaul R, Naorem A, Kateriya S. Modulation of cyclic nucleotide-mediated cellular signaling and gene expression using photoactivated adenylyl cyclase as an optogenetic tool. Sci Rep 21;7(1):12048, 2017.
  • Haokip N, Naorem A. Functional characterisation of parvulin-type peptidyl prolyl cis-trans isomerase, PinA in Dictyostelium discoideum. Biochem Biophys Res Commun. 482(2):208-214, 2017.
  • Kalleda N, Naorem A, Manchikatla RV. Targeting fungal genes by diced siRNAs: a rapid tool to decipher gene function in Aspergillus nidulans. PLoS One. 8(10):e75443, 2013.
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