Tapasya Srivastava

My lab is interested in studying the various mechanisms which contribute to induction of genomic instability in primary tumors and in model systems which mimic the tumor microenvironment. We use hypoxia as a model of cellular stress and study its implications in stress induced molecular and cellular changes in the tumor cell. Addressing this issue with reference to efficacy of small molecule modulators with/without genotoxic agents has tremendous implications in cancer therapy.
Research Interest
The lab focuses on the various cellular and molecular mechanisms regulated by the hypoxic microenvironment present in solid tumors. Genetic and epigenetic features work along with the hypoxia inducible factors to modulate the outcome of solid tumors.  Some of the research areas we work on, include:
1) Understanding the response of tumor cells to chemotherapeutic agents in the hypoxic microenvironment. Our interest lies in understanding the molecular mechanisms associated with it, attempting to enhance the efficacy in the chemo-resistant hypoxic microenvironment with alternate molecules, and searching for novel bio-markers in the hypoxic back-drop.
2)  Determining the role of integrins in epithelial to mesenchymal transition and cancer progression. Hypoxia inducible factors emerge as key modulators of most known pathways of growth and survival. We are looking to elucidate the intervening role hypoxia inducible factors further. The contribution of the genetic component to the HIF mediated regulation is extremely challenging. Towards this, we are also exploring the association of the nicotine receptor signaling networks and HIF signaling pathway in lung cancer.
3) Determining the role of non-coding RNA and epigenetic regulation in the hypoxic microenvironment, as a contributor to the disease prognosis, is of great interest to us. The epigenome comprises of a number of modulators and we are exploring the chromatin machinery to decipher the mechanism associated with cellular and molecular changes that it brings about in the hypoxic microenvironment. One of the cellular phenotypes that hypoxia is known to exhibit is that with stem-cell like characteristics. We are exploring the mechanistic role of the epigenetic machinery in this and other related phenomena with the hypoxic microenvironment.


Lab Members

  • Dr. Shivani Mittal (Postdoctoral fellow)
  • Shrikant Pradhan (PhD students)
  • Pankaj Prasad (PhD students)
  • Namita Pandey (PhD students)
  • Prabhjot Kaur (PhD students)
  • Divyank Mahajan (PhD students)
  • Mihir Trivedi (Junior Research Fellow)


Few Recent Publications

  1. Singh P, Jenkins LM, Horst B, Alers V, Pradhan S, Kaur P, Srivastava T, Hempel N, Győrffy B, Broude EV, Lee NY, Mythreye K. Inhibin is a novel paracrine factor  for tumor angiogenesis and metastasis. Cancer Res. 2018 Mar 13.
  2. Pandey N, Pal S, Sharma LK, Guleria R, Mohan A, Srivastava T. SNP rs16969968 as a Strong Predictor of Nicotine Dependence and Lung Cancer Risk in a North Indian Population. Asian Pac J Cancer Prev. 2017 Nov 26;18(11):3073-3079.
  3. Prasad P, Mittal SA, Chongtham J, Mohanty S, Srivastava T. Hypoxia-Mediated Epigenetic Regulation of Stemness in Brain Tumor Cells. Stem Cells. 2017 Jun;35(6):1468-1478.
  4. Pandey N, Dhiman S, Srivastava T, Majumder S. Transition metal oxide nanoparticles are effective in inhibiting lung cancer cell survival in the hypoxic tumor microenvironment. Chem Biol Interact. 2016 Jul 25;254:221-30.
  5. Pradhan S, Mahajan D, Kaur P, Pandey N, Sharma C, Srivastava T. Scriptaid overcomes hypoxia-induced cisplatin resistance in both wild-type and mutant p53 lung cancer cells. Oncotarget. 2016 Nov 1;7(44):71841-71855.

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